University of Nevada, Las Vegas Ph.D. Winner Leads Antibiotic-Resistant Shigella Research

UNLV’s Rising Star: Taylor Gerson’s Breakthrough in Antibiotic-Resistant Shigella

In the competitive arena of graduate research, few achievements stand out as clearly as Taylor Gerson’s work on antibiotic‑resistant Shigella. A Ph.D. candidate in the School of Life Sciences, Gerson has combined rigorous molecular biology with a clear vision for public health impact. Her research, which earned her the 2025 Rebel Grad Slam title, focuses on the bacterial virulence mechanisms that allow Shigella flexneri to evade antibiotics and infect human cells.

For students and professionals interested in microbiology, infectious disease, or drug discovery, Gerson’s story offers a roadmap: identify a pressing global problem, collaborate across disciplines, and communicate findings effectively. Below we break down her journey, the science behind her discoveries, and how you can apply similar strategies in your own career.

The Significance of Shigella and Antibiotic Resistance

Why Shigella Matters

Shigella flexneri is responsible for millions of diarrheal illnesses worldwide each year. Its ability to invade intestinal epithelial cells and trigger inflammation makes it a formidable pathogen. In 2025, the World Health Organization highlighted Shigella as one of the top five bacteria contributing to the projected 50 million deaths by 2050 if new treatments are not developed.

Antibiotic Resistance: A Growing Threat

Traditional antibiotics are losing efficacy against Shigella due to the acquisition of resistance genes. This resistance not only complicates treatment but also increases the risk of outbreaks in vulnerable populations. Researchers worldwide are racing to identify novel drug targets that can bypass existing resistance mechanisms.

Gerson’s Research Focus: VirB and CTP Interaction

Uncovering the Molecular Switch

Gerson’s work zeroed in on a protein called VirB, a key regulator that flips Shigella’s virulence genes on and off. By partnering with chemist Ron Gary, her team discovered that VirB must bind to a small molecule, cytidine triphosphate (CTP), to activate these genes. When VirB’s binding site is altered so it can no longer interact with CTP, the bacteria lose the ability to express the genes necessary for infection.

This finding suggests that the VirB‑CTP interface could serve as a drug target. Inhibitors designed to block this interaction might render Shigella harmless without relying on traditional antibiotics, offering a new therapeutic strategy.

Implications for Drug Development

Targeting bacterial regulatory proteins is a relatively untapped area in antimicrobial research. Gerson’s discovery opens a pathway for designing molecules that specifically disrupt bacterial gene expression, potentially reducing the selective pressure that drives resistance. Pharmaceutical companies are already expressing interest in this approach, and Gerson’s publications in top-tier journals have accelerated the conversation.

From Classroom to Lab: Gerson’s Academic Journey

Early Interests and the Shift to Life Sciences

Growing up in suburban Chicago, Gerson balanced a passion for performance with a curiosity about science. Initially pursuing a pre‑med track, she found the clinical focus limiting and sought a more research‑oriented path. A summer internship through the NSF Research Experience for Undergraduates at UNLV exposed her to molecular microbiology and sparked a lasting interest in bacterial pathogenesis.

Mentorship and the Role of the Wing Lab

Professor Helen Wing’s lab became a pivotal influence. Wing’s leadership style—combining rigorous science with supportive mentorship—helped Gerson build confidence in presenting complex data. Wing’s guidance was instrumental in Gerson’s decision to apply for the Ph.D. program and later to enter the Rebel Grad Slam competition.

The Rebel Grad Slam: A Platform for Emerging Researchers

Competition Structure and Impact

The Rebel Grad Slam is a 3‑minute thesis competition that invites graduate and professional students to showcase their research to a broad audience. Over 100 participants compete in preliminary rounds, with 35 advancing to the semifinals and nine to the finals. The event not only awards scholarships but also provides a forum for networking and skill development.

Gerson’s Winning Thesis and Presentation Skills

Gerson’s thesis succinctly explained the VirB‑CTP interaction and its therapeutic potential. Her presentation was praised for clarity, visual aids, and the ability to translate complex molecular biology into accessible language. She credits her success to practice sessions with peers and the supportive environment fostered by her lab and the Graduate College.

Implications for Global Health and Future Directions

Potential Drug Targets and Treatment Strategies

By identifying a non‑traditional drug target, Gerson’s research could lead to the development of small‑molecule inhibitors that suppress Shigella virulence. Such drugs would complement existing antibiotics and reduce the likelihood of resistance emergence. Clinical trials would be the next step, requiring collaboration with pharmaceutical partners and regulatory agencies.

Next Steps: From UNLV to Scripps Research

After graduation, Gerson will join the Racki Lab at Scripps Research in San Diego, where she will continue to explore bacterial regulatory mechanisms. This transition underscores the importance of building a strong publication record and networking across institutions to secure post‑doctoral opportunities.

How Students Can Get Involved and Advance Their Careers

Research Opportunities at UNLV

UNLV offers a range of research programs, including the NSF REU, graduate assistantships, and interdisciplinary projects that bridge microbiology, chemistry, and computational biology. Students interested in antibiotic resistance should seek labs that focus on pathogen genomics or drug discovery.

For more information on available research positions, visit the UNLV Graduate College research page.

Building a Strong Presentation Portfolio

Effective communication is as critical as experimental skill. Graduate students should practice presenting their work at seminars, conferences, and informal gatherings. The Rebel Grad Slam is one example, but local symposiums and journal clubs also provide valuable feedback.

Consider joining student organizations such as the American Society of Microbiology Student Chapter or the UNLV Biology Graduate Organization (BIOS) to refine your presentation style and expand your professional network.

Conclusion and Call to Action

Taylor Gerson’s journey from a curious undergraduate to a celebrated Ph.D. researcher illustrates the power of mentorship, interdisciplinary collaboration, and clear communication. Her work on antibiotic‑resistant Shigella not only advances scientific understanding but also offers a tangible path toward new treatments that could save millions of lives.

Students and professionals looking to make an impact in microbiology should consider the following steps:

• Identify a high‑impact research question, such as antibiotic resistance or pathogen virulence.
• Seek mentorship from experienced faculty and engage in collaborative projects across departments.
• Develop strong presentation skills through competitions like the Rebel Grad Slam or local conferences.
• Publish findings in reputable journals and pursue post‑doctoral opportunities that align with your research goals.

Ready to take the next step in your research career? Submit your application today and explore the graduate programs that can help you turn ideas into real‑world solutions.

Have questions about pursuing a Ph.D. in microbiology or preparing for a thesis competition? Write to us! We’re here to support your academic journey.

Want to learn more about antibiotic‑resistant pathogens and emerging drug targets? Explore our related articles for further reading and stay updated on the latest research breakthroughs.